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the easiest solution would be to write the app in HTML5. You can package an HTML5 app to work on mobile platforms as any other native app. Intel has a great HTML5 development platform in beta right now. You should try it out: http://software.intel.com/en-us/html5
You can use Titanium SDK , it's provides community developers with an unmatched ability to create quality native, mobile web or rich hybrid applications to all platforms from a single code base, using JavaScript. With over 5,000 APIs, Titanium allows you to deliver an immersive user experience at a fraction of the time compared with traditional native platforms, and without compromise.
It all depends on what you are going to do. If your app needs GPS, the accelerometer, or is very graphics intensive, then a native app is the only way to go.