If a process (running with or without Inspector XE) fails with a insufficient memory error while the machine seems to have plenty left, a vm.max_map_count overrun could be the problem.
Here's how to find out what the per process limit is:
> vm.max_map_count = 65530
And how to estimate how many mappings your process us using
cat /proc/<process id>/maps | wc -l
I've seen the problem occur for a process (Autodesk's maya) that uses the mmap system call directly for many smallish allocations.