Electrical specifications for each power source are as follows:
The total combined power for +V1P8V, +V3P3V and +V5P0V should not exceed .4.5 W given 12 V to VDCIN. This is assuming that the USB ports are not sourcing 900 mA to devices for OTG mode. If your use case requires full OTG current, then the OTG power should be subtracted from 4.5 W to find your new max power allowed to the IO breakout connectors. It is not recommended to operate both USB-C and USB-A ports at full OTG current loading simultaneously.