This metric estimates how often memory load accesses were aliased by preceding stores (in the program order) with a 4K address offset. Possible false match may incur a few cycles to re-issue a load. However, a short re-issue duration is often hidden by the out-of-order core and HW optimizations. Hence, you may safely ignore a high value of this metric unless it propagates up into parent nodes of the hierarchy (for example, to L1_Bound).
A significant proportion of cycles is spent dealing with false 4k aliasing between loads and stores.
Use the source/assembly view to identify the aliasing loads and stores, and then adjust your data layout so that the loads and stores no longer alias. See the Intel 64 and IA-32 Architectures Optimization Reference Manual for more details.