I've been working with the Intel® Texture Works Beta Plugin for Photoshop, modifying DDS textures in for Fallout 4. I noticed a possible problem with the Intel plugin, which I hope the following will illustrate.
Here is the DDS opened with NVIDIA Texture Tools for Adobe Photoshop:
Notice that (a) there is an Alpha Channel, and (b) the RGB image is edge-to-edge, not trimmed to the alpha. The 3 blank poster images above the eyes are visible.
Here is the same DDS opened with the Intel® Texture Works Plugin for Photoshop:
Notice that the Alpha Channel has been applied to the image, removing the original RGB content. There is no distinct Alpha Channel to edit, only the transparency applied to the RGB. The 3 blank poster images above the eyes have disappeared.
I suspect that one of two things is true:
1) Those 3 blank posters are used as a texture asset in-game, and the Intel plugin is mistakenly applying the alpha, damaging the original content.
2) The plugin is being accurate and efficient by removing alpha'd content, potentially saving filespace.
I don't have the means to discover which of those is more true. But it seems that forcibly removing the alpha may be the incorrect approach.