About one week ago was posted a bigger test. The ref-seq was about 50-60 mb. It costs some time to read it amd put it in the buffer. What do you think about parallel I/O ? There are lots of possibilities with MPI, but what's about OpenMP, or Intel-stuff ? The data will be probably one one hard disk, so we don't have lots of options, I fear (because of only one head). What do you think? What do the organizers think? do You want us to do I/O parallel ?