One of the Intel® Modern Code Developer Challenge winners, Daniel Falguera, describes many of the optimizations he implemented and why some didn't work.
Cython* is a superset of Python* that additionally supports C functions and C types on variable and class attributes. Cython generates C extension modules, which can be used by the main Python program using the import statement.
One Stop for Optimizing Your Data Center From AI to Big Data to HPC: End-to-end Solutions
By Taylor Kidd, Intel Corporation
This article is essentially a collection of blogs I wrote on the same subject. The differences are simply a degree of formalism.